Jared Padalecki & Misha Collins Join Jensen Ackles in The Boys Final Season

Jared Padalecki and Misha Collins are set to guest star in the fifth and final season of The Boys, reuniting with their fellow Supernatural alum, Jensen Ackles. There's no word yet on what their roles will be. Padalecki and Ackles, who starred together on Supernatural for 15 seasons, are not the only Supernatural alumni to appear on The Boys. The show has also featured Jim Beaver (Robert Singer), Jeffrey Dean Morgan (Joe Kessler), and Rob Benedict (Splinter).

Supernatural ran from 2005 to 2020, and Misha Collins, who played Castiel (among other roles), was a key part of the show for 12 seasons.

Eric Kripke, creator of The Boys, eyed Padalecki to play a role in the series for years, saying in the past, "I feel like I have to complete my game of ‘Supernatural Pokémon and I have my one big one - very big one - left to catch." He later revealed that he was in talks with Padalecki for a role in the final season, adding, "I love him, and you try to work with people that you love."

Currently in production, the final season of The Boys stars Karl Urban, Jack Quaid, Laz Alonso, Tomer Capone, Karen Fukuhara, Antony Starr, Erin Moriarty, Dominique McElligott, Jessie T. Usher, Nathan Mitchell, Chace Crawford, Colby Minifie, Claudia Doumit, and Giancarlo Esposito.

In addition to the main series, the college-set spinoff Gen V debuted in 2023 and was renewed for a second season. The The Boys franchise has also spawned an animated spinoff, The Boys Presents: Diabolical, and the upcoming series Vought Rising, which will feature Padalecki.