The Fountain (2006)

What if you could live forever? The Fountain is an odyssey about one man's eternal struggle to save the woman he loves. His epic journey begins in 16th-century Spain, where conquistador Tomas (Hugh Jackman) commences his search for the Fountain of Youth, the legendary entity believed to grant immortality. As modern-day scientist Tommy Creo, he desperately struggles to find a cure for the cancer that is killing his beloved wife, Isabel (Rachel Weisz). Traveling through deep space as a 26th-century astronaut, Tom begins to grasp the mysteries that have consumed him for a millennium. The three stories converge into one truth, as the Thomas of all periods -- warrior, scientist, and explorer -- comes to terms with life, love, death and rebirth.